Saturday 4 December 2010

Proteomics - The Study Of Proteins, Particularly Structure and Function


Proteomics - General Facts:
  • The term "Proteome" comes from the blending of the words "Protein" & "Genome".
  • An organism's proteome consists of it's entire complement of proteins.
  • Proteomics deals with the large-scale study of proteins, especially structure & functions.
  • After genomics, proteomics is considered the next essential area of study to facilitate the understanding of biological systems.
Proteomics - History:
  • The term "proteomics" was first coined by Marc Wilkins in 1994, whilst a PhD student.[1]
Proteomics - Study Approaches:
  • See Table.
  • Broad-based approach - understand proteome as a whole.
  • Focused approach - understand specific protein information.
Post-translational Modification Of Proteins:
  • Acetylation
  • Glycosylation
  • Methylation
  • Nitrosylation
  • Oxidation
  • Phosphorylation
  • Ubiquitination
References:
[1] - UNSW Staff Bio: Professor Marc Wilkins (link)

Image: Table showing pros & cons of broad-based vrs focused approach to proteomics.
Image Credit: By Mccrearym on Wikipedia (public domain)
Tags: Acetylation - Genome - Genomics - Glycosylation - Methylation - Nitrosylation - Oxidation - Phosphorylation - Protein - Proteomics - Ubiquitination
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