Proteomics - The Study Of Proteins, Particularly Structure and Function

Proteomics - General Facts:

• The term "Proteome" comes from the blending of the words "Protein" & "Genome".
• An organism's proteome consists of it's entire complement of proteins.
• Proteomics deals with the large-scale study of proteins, especially structure & functions.
• After genomics, proteomics is considered the next essential area of study to facilitate the understanding of biological systems.

Proteomics - History:

• The term "proteomics" was first coined by Marc Wilkins in 1994, whilst a PhD student.[1]

Proteomics - Study Approaches:

• See Table.
• Broad-based approach - understand proteome as a whole.
• Focused approach - understand specific protein information.

Post-translational Modification Of Proteins:

• Acetylation
• Glycosylation
• Methylation
• Nitrosylation
• Oxidation
• Phosphorylation
• Ubiquitination

References:

[1] - UNSW Staff Bio: Professor Marc Wilkins (link)

Image: Table showing pros & cons of broad-based vrs focused approach to proteomics.

Image Credit: By Mccrearym on Wikipedia (public domain)

Tags: Acetylation - Genome - Genomics - Glycosylation - Methylation - Nitrosylation - Oxidation - Phosphorylation - Protein - Proteomics - Ubiquitination

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